| 2010 Patriots Regular Season | |||||
| Date | Time | H/V | Team | TV/Score | Rec |
| Sun 9/12/2010 | 1:00 PM | vs | Bengals | W, 38-24 | 1-0 |
| Sun 9/19/2010 | 4:15 PM | @ | Jets | L, 28-14 | 1-1 |
| Sun 9/26/2010 | 1:00 PM | vs | Bills | W, 38-30 | 2-1 |
| Mon 10/4/2010 | 8:30 PM | @ | Dolphins | W, 41-14 | 3-1 |
| Sun 10/10/2010 |
Bye |
||||
| Sun 10/17/2010 | 1:00 PM | vs | Ravens | W, 23-20 |
4-1 |
| Sun 10/24/2010 | 4:15 PM | @ | Chargers | CBS | – |
| Sun 10/31/2010 | 4:15 PM | vs | Vikings | FOX | – |
| Sun 11/7/2010 | 1:00 PM | @ | Browns | CBS | – |
| Sun 11/14/2010 | 8:20 PM | @ | Steelers | NBC | – |
| Sun 11/21/2010 | 4:15 PM | vs | Colts | CBS | – |
| Thu 11/25/2010 | 12:30 PM | @ | Lions | CBS | – |
| Mon 12/6/2010 | 8:30 PM | vs | Jets | ESPN | – |
| Sun 12/12/2010 | 1:00 PM | @ | Bears | CBS | – |
| Sun 12/19/2010 | 8:20 PM | vs | Packers | NBC | – |
| Sun 12/26/2010 | 1:00 PM | @ | Bills | CBS | – |
| Sun 1/2/2011 | 1:00 PM | vs | Dolphins | CBS | – |
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