Here are the Boston Red Sox 2010 MLB Draft picks for rounds 16 through 30. We’ll be back tomorrow with rounds 31-50 once the draft is completed.
| Pick (Rd) | Name | School | POS | B/T | Class |
| 503 (16th) | Adam Duke | Spanish Fork HS (UT) | P | R/R | HS |
| 533 (17th) | Jason Garcia | Land O’Lakes HS (FL) | P | R/R | HS |
| 563 (18th) | Dallas Chadwick | Shasta HS (CA) | P | R/R | HS |
| 593 (19th) | Eric Jaffe | Bishop O’Dowd School (CA) | P | R/R | HS |
| 623 (20th) | Roderick Shoulders | Brandon HS (FL) | C | L/R | HS |
| 653 (21st) | Mason Justice | Holland Hall HS (OK) | P | R/R | HS |
| 683 (22nd) | Trace Tam Sing | Newport HS (WA) | P | R/R | HS |
| 713 (23rd) | Austin Wright | Chipola JC | P | L/L | J2 |
| 743 (24th) | Sean Yost | Nebraska | P | R/R | JR |
| 773 (25th) | Tyler Lockwood | TCU | P | R/R | SR |
| 803 (26th) | Dillon Overton | Weatherford HS (OK) | P | L/L | HS |
| 833 (27th) | Jay Gonzalez | Freedom HS (FL) | CF | L/L | HS |
| 863 (28th) | Michael Wagner | Centennial HS (NV) | P | R/R | HS |
| 893 (29th) | Paul Davis | Pensacola JC | P | R/R | J2 |
| 923 (30th) | Desean Anderson | Ragsdale HS (NC) | CF | R/R | HS |
