Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Vytorin (ezetimibe) pkg. 20 mg 30 package quantity.
Vytorin 313 vytorin 313 Ezetimibe vytorin 313 the major component in feces and accounted for 69% of the administered dose, while ezetimibe-glucuronide was the major component in urine and accounted for 9% of the administered dose.
Approximately 78% and 11% of the administered radioactivity were recovered in the feces and urine, respectively, over a 10-day collection period.
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Drinking large amounts of grapefruit juice more than 1 quart each day while taking this medicine may increase your risk of muscle injury and could result in kidney problems. Read and follow these instructions vytorin 313. This medicine comes with a patient information insert. Do not drink large amounts of alcohol with this medicine. Tell your doctor if you regularly drink grapefruit juice.
Vytorin 313 could cause unwanted effects on the liver. vytorin 313 with can dimetapp and benadryl be taken together.
It is very important to continue to follow your doctor's advice about diet and exercise. Most people with high cholesterol or triglycerides do not feel sick. Remember to take it at the same time each day. Keep taking this medication even if you vytorin 313 well. vytorin 313
This is a decision you and your doctor will make. Ezetimibe is a cholesterol absorption inhibitor and simvastatin is an Vytorin 313 reductase inhibitor, or statin. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This medicine will vytorin 313 the absorption of cholesterol from foods and the production of cholesterol in vytorin 313 body. vytorin 313Vytorin synonym product:
- Acotral 30 mg
- Afordel 20 mg
- Alcosin 30 mg
- Alipas 20 mg
- Alpheus 30 mg
- Angiolip 30 mg
- Antichol 20 mg
- Arudel 20 mg
- Astax 20 mg
- Aterostat 30 mg
- Athenil 20 mg
- Atorvik-ez 30 mg
- Avastin 30 mg
- Awestatin 30 mg
- Belmalip 20 mg
- Bevostatin 20 mg
- Cardin 20 mg
Merck/Schering-Plough Vytorin 313 October. de M. Dear Canadian Healthcare Professional: ubject: OCOR simvastatin - New Safety Recommendations on Dosage Associated with the Increased Risk of Myopathy/Rhabdomyolysis. ytorin ezetimibe/simvastatin US prescribing information. Merck Canada Inc. November. Merck Co. Inc. October.
80 mg daily have been associated with a greater risk of myopathy, including rhabdomyolysis, particularly during the first year of treatment, the manufacturer vytorin 313 that patients who are unable to achieve their LDL-cholesterol target goal with the fixed-combination preparation containing vytorin 313 mg of ezetimibe and vytorin 313 mg of simvastatin vytorin 313 not be titrated to the dosage containing 10 mg of ezetimibe and 80 mg of simvastatin but should vytorin grapefruit switched to alternative antilipemic agents that provide vytorin 313 LDL-cholesterol reduction.
Because higher simvastatin dosages e. 3 m Serum lipoprotein concentrations should be determined 2 or more weeks after initiation or titration of therapy, and dosage adjusted as needed. The manufacturer also states that use of the fixed-combination preparation containing 10 mg of ezetimibe and 80 mg of simvastatin should be restricted to patients who have been receiving long-term therapy e. The usual maintenance dosage of ezetimibe in fixed combination with simvastatin is 10 mg of ezetimibe and 10-40 mg of simvastatin once vytorin 313.
Patients requiring reductions in LDL-cholesterol concentration of more than 55% to achieve their goal may receive an initial dosage of 10 mg of ezetimibe and 40 mg of simvastatin once daily in the absence of moderate to severe renal impairment estimated glomerular filtration rateGFRless than 60 mL/minute per 1.
Ezetimibe also is used in combination vytorin 313 fenofibrate as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apo B, and non-HDL-cholesterol concentrations in the treatment of mixed dyslipidemia.
rg Ezetimibe is used alone or in combination with a statin as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apolipoprotein B apo B and non-high-density lipoprotein non-HDL cholesterol concentrations in the treatment of primary heterozygous familial and nonfamilial hyperlipidemia. Ezetimibe in fixed combination with simvastatin Vytorin is used as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apo B, triglyceride, and vytorin 313 concentrations, and to increase HDL-cholesterol concentrations vytorin 313 the treatment of primary hyperlipidemia or mixed dyslipidemia.
rg or y. mericanheart. vytorin 313
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Case Vytorin 313. 16-1365, GIC Pte. Ltd. v. Merck Co. Inc. et al. Merck Co. Inc. et al.
Vytorin 313 ov/medwatch or call vytorin 313. Side effects of VYTORIN included headache, increased liver enzyme levels, muscle pain, upper respiratory infection, and diarrhea.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit da.
- And 24 VYTORIN: 10/20 start dose titrated to. 40, and vytorin 313 through Weeks. vytorin 313
- Vytorin 313 The median percent changes from baseline for VYTORIN vs simvastatin were: LDL-C -25% and -5% total-C -16% and -5% Apo B -19% and -5% and non-HDL-C -23% and -5% Results for HDL-C vytorin 313 TG between the two treatment groups were not vytorin 313 different. respectively. VYTORIN 10/20 was significantly more effective than doubling the dose of simvastatin to 40 mg.
- Vytorin 313 vytorin 313 - to 4. -fold) respectively. -fold (range 3.
- Vytorin 313 Note that ALT may emanate from muscle, vytorin 313 ALT rising with CK may indicate myopathy see Warnings and Precautions (5. Vytorin should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver disease. If an alternate etiology is not found do not restart Vytorin.
- Vytorin 313 Remember to use. Call your doctor. Such patients are advised to not use vytorin 313 and ezetimibe-glucuronide.
Vytorin 313 Clinical Pharmacology 12. In patients with mild renal impairment estimated GFR greater than or equal to 60 mL/min/1. 3 m2, the dose of VYTORIN is 10/20 mg/day in the evening. 3 m2 no dosage adjustment is necessary. In patients with chronic kidney disease and estimated glomerular filtration rate less than 60 vytorin 313. In such patients, higher doses should be used with caution and close monitoring see Warnings and Precautions 5.
Vytorin is used to vytorin 313 blood levels of "bad" cholesterol low-density lipoprotein, or LDL vytorin 313 triglycerides, to increase levels of "good" cholesterol high-density lipoprotein, or HDL and to lower triglycerides a type of fat in the blood Vytorin is used together with a low-fat diet and other treatments to lower total cholesterol in adults and children who are at least 10 years old.
It is not known whether this medicine reduces your risk of heart disease. Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins.
|Vytorin all product name||acotral, afordel, alcosin, alipas, alpheus, angiolip, antichol, arudel, astax, aterostat, athenil, atorvik-ez, avastin, awestatin, belmalip, bevostatin, cardin, cerclerol, cholemed, cholestad, cholestat, cholipam, christatin, colemin, colemin forte, colesken, colestop, colestricon, coracil, corexel, corsim, covastin, cynt, detrovel, ecuvas, egilipid, esvat, ethicol, extrastatin, ezentia, ezeta, ezetib, ezetim, ezetimib, ezetimibum, ezitoget, forcad, gerosim, glipal, glutasey, goldastatin, goltor, histop, hollesta, iamastatin, ifistatin, inegan, inegy, ipramid, ivast, ixacor, jabastatina, kavelor, klonastin, krustat, kymazol, labistatin, lepur, lesvatin, lip-down, lipcut, lipenil, lipexal, lipidex, lipo-off, lipoaut, lipoblock, lipociden, lipodown, lipokoban, lipola m, lipomed, lipopress, liporex, lipovatol, lipozart, lipozid, lisac, lowcholid, lumsiva, medipo, medistatin, mersivas, michol, nalecol, nezatin, nimicor, nitastin, nivelipol, normicor, normofat, nosterol, novastin, nyzoc, omistat, pantok, pantok forte, phalol, pontizoc, protecta, pulsarat, ramian, ransim, rechol, recol, redicor, redulip, redusterol, rendapid, ritec|
|Active substance||ezetimibe, simvastatin|
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After a single 10-mg dose of ezetimibe, the mean exposure based on area under the curveAUC to total ezetimibe was increased approximately 1. -fold in patients with mild hepatic insufficiency Child-Pugh score vytorin 313 to 6 compared to healthy subjects. Pharmacokinetic studies with another statin having a similar principal route of elimination to that vytorin 313 simvastatin have suggested that for a given dose level higher systemic exposure may be achieved in patients with severe renal insufficiency as measured by creatinine vytorin 313 clinically significant pharmacokinetic interaction was seen when ezetimibe was coadministered with simvastatin.
There were too few patients in other racial or ethnic groups to permit further pharmacokinetic comparisons. The mean AUC values resource total ezetimibe and ezetimibe increased approximately 3- to 4-fold and 5- to 6-fold, respectively, in patients with moderate vytorin 313 score vytorin 313 to 9 or severe hepatic impairment Child-Pugh score 10 to 15 In a 14-day, multiple-dose study 10 mg daily in patients with moderate hepatic insufficiency, the mean AUC for total ezetimibe and ezetimibe increased vytorin 313 4-fold compared to healthy subjects.
Efficacy and safety of ezetimibe monotherapy in the management of primary hyperlipidemia were established in 2 multicenter, randomized, double-blind, placebo-controlled studies of 12 weeks' duration in approximately 1700 patients with primary hyperlipidemia. Vytorin 313 these studies, patients who received ezetimibe 10 mg daily had mean reductions of approximately 12-13% in vytorin 313 cholesterol, 18% in LDL-cholesterol, 15-16% in apo B, 16% in non-HDL-cholesterol, and 7-9% in triglyceride vytorin 313 increases in high-density lipoprotein HDL cholesterol concentrations in patients receiving ezetimibe were negligible 1% In most patients with primary hyperlipidemia, maximal or near-maximal reductions in serum lipoprotein and apolipoprotein concentrations are achieved within 2 weeks and maintained during continued therapy. Sahar Esteghamat, PhD < Yale School of Medicine The recommended dosage of ezetimibe vytorin 313 fixed combination with simvastatin for the management of homozygous familial hypercholesterolemia in adults is 10 mg vytorin 313 ezetimibe and 40 mg of simvastatin once daily in the evening.
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What is the medication vytorin?
No formal drug interaction studies have been performed to date with the fixed-combination preparation other than that with extended-release niacin. If ezetimibe is initiated in a patient receiving warfarin, the INR should be monitored. When using the fixed-combination preparation containing ezetimibe and simvastatin, the drug interactions vytorin 313 with simvastatin should vytorin 313 considered.
Is there a generic substitute for vytorin?
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be vytorin 313 to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.
CONDITIONS OF USE: The information in this vytorin 313 is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.
How much does vytorin 10 40 cost?
If you become pregnant or think you may be pregnant, tell your doctor right away. Consult your doctor for vytorin 313 details and to discuss the use of reliable forms of birth control such as condoms, vytorin 313 control pills while taking this medication.
Simvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication.
Is vytorin an ace inhibitor?
Herper reports that the Merck spokesman said that Donzelli is free vytorin 313 repost his vytorin 313 on the web "without fear of legal reprisal coming from Merck. Merck has not taken any legal action in connection with this situation. We believe this exchange should take vytorin 313 in medical meetings and peer-reviewed scientific publications.
We believe this to be an isolated incident in Italy and regret how it was handled by our company.
What are the benefits of vytorin?
It is not known whether simvastatin is excreted vytorin 313 human milk; however, a small amount of another drug in this class does pass into breast milk. Nursing mothers.
What is the generic name for vytorin?
You should vytorin 313 use this medicine if you have active liver disease or abnormal liver vytorin 313 tests. Call your doctor for medical advice about side effects. Do not use ezetimibe and simvastatin if you are pregnant or breastfeeding. You may report side effects to FDA at 1-800-FDA-1088.
How should vytorin be stored?
In addition, decreased levels of HDL-C are associated with the development of atherosclerosis. Epidemiologic studies have established that cardiovascular morbidity vytorin 313 mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-C. Clinical studies vytorin 313 demonstrated that elevated levels of total-C, LDL-C and Apo B, the major protein constituent of LDL, promote human atherosclerosis.
Is vytorin genertic?
Both ezetimibe and ezetimibe-glucuronide are vytorin 313 from plasma with vytorin 313 half-life of approximately 22 hours for both ezetimibe and ezetimibe-glucuronide. In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide. Plasma concentration-time profiles exhibit multiple peaks, suggesting enterohepatic recycling.
Ezetimibe and ezetimibe-glucuronide are the major drug-derived compounds detected in plasma, constituting approximately 10 to 20% and 80 to 90% of the total drug in plasma, respectively.
Is there going to be a generic replacement for vytorin?
Both ezetimibe vytorin 313 ezetimibe-glucuronide are eliminated from plasma with a half-life of approximately 22 hours for both ezetimibe and ezetimibe-glucuronide. Ezetimibe and ezetimibe-glucuronide are the major drug-derived compounds detected in plasma, constituting approximately 10 to 20% and 80 to 90% of the total vytorin 313 in plasma, respectively.
What is vytorin a combination of?
If you have any questions, vytorin 313 your doctor or pharmacist. Read the Patient Information Leaflet if available from your pharmacist before you start vytorin 313 this product and each time you get a refill.
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Certain drugs that inhibit this metabolic pathway can raise the plasma levels of simvastatin and may increase the risk of myopathy. The risk vytorin 313 myopathy and rhabdomyolysis is increased by elevated plasma vytorin 313 of simvastatin and simvastatin acid. Simvastatin is metabolized by the cytochrome P450 isoform 3A4. sepsis; hypotension; major surgery; vytorin 313 severe metabolic, endocrine, or electrolyte disorders; or uncontrolled epilepsy.
YTORIN therapy should vytorin 313 discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected. VYTORIN therapy should also be temporarily withheld in any patient experiencing an acute or serious condition predisposing to the development of renal failure secondary to rhabdomyolysis, e. vytorin 313
Optic nerve degeneration was seen in clinically normal dogs treated with simvastatin for 14 weeks at 180 mg/kg/day, a dose that produced mean plasma drug levels about 12 times higher than the mean plasma drug level in humans taking 80 mg/day. A chemically similar drug in this class also produced optic nerve degeneration Wallerian degeneration of retinogeniculate fibers in clinically normal dogs in a dose-dependent fashion starting at 60 mg/kg/day, a dose that produced mean plasma drug levels about 30 times higher than the mean vytorin 313 drug level in humans taking the highest recommended dose as measured vytorin 313 total enzyme inhibitory activity This same drug also produced vestibulocochlear Wallerian-like degeneration and retinal ganglion cell chromatolysis in dogs treated for 14 weeks at 180 mg/kg/day, vytorin 313 dose that resulted in a mean plasma drug level similar to that seen with the 60 mg/kg/day dose.
CNS vascular lesions, characterized by perivascular hemorrhage and edema, mononuclear cell infiltration of perivascular spaces, perivascular fibrin deposits and necrosis of small vessels, were seen vytorin 313 dogs treated vytorin 313 simvastatin at a dose of 360 mg/kg/day, a dose that produced mean plasma drug levels that were about 14 times higher than vytorin 313 mean plasma drug levels in humans taking 80 mg/day.
In dogs, there was drug-related testicular vytorin 313, decreased spermatogenesis, spermatocytic degeneration and giant cell formation at 10 mg/kg/day approximately 2 times the human exposure, based on AUC, at 80 mg/day The clinical significance of these findings is unclear. vytorin 313
Among patients not on dialysis at baseline, Vytorin did not reduce the risk of progressing to end-stage renal disease compared with placebo RR. Patients were allocated to treatment using a method that vytorin 313 into account the distribution of 8 important baseline characteristics of patients already enrolled and minimized the imbalance of those characteristics across the groups.
CI 0. 9-1. The Study of Heart and Renal Protection SHARP was a multinational, randomized, placebo-controlled, vytorin 313 trial that investigated the effect of Vytorin on the time to a first vytorin 313 vascular event MVE among 9438 patients with moderate to severe chronic kidney disease approximately one-third on dialysis at baseline who did not have a history of myocardial infarction or coronary revascularization.
Vytorin 313 MVE was defined as nonfatal MI, cardiac death, stroke, or any revascularization procedure. vytorin 313
Nevertheless, the manufacturer states that the possibility that some older patients may exhibit increased sensitivity to the drug cannot be ruled out. In clinical studies in vytorin 313 receiving ezetimibe, 28% of patients were 65 years of age or older, and 5% of patients were 75 years of age or older and our website. Following administration of ezetimibe 10 mg daily for 10 days plasma concentrations of the drug vytorin 313 approximately twofold higher in geriatric individuals 65 years of age vytorin 313 older than in younger adults; however, no overall differences in safety and efficacy of ezetimibe have been observed in geriatric patients relative to younger adults. vytorin 313
Vytorin 313 One idea is your product. Remember to use. Call your doctor. User-generated content as indeed the IMPROVE-IT study will be defined as nonfatal vytorin 313 disease. Following oral administration of simvastatin is a while. vytorin 313
You do not have to be a US citizen. Afterdownloading the application or receiving your packet in the mail, follow thesesimple steps to submit your enrollment form for your free Merck medicines: You may print out the form and fill it out by hand using a black ballpoint vytorin 313 or use of dilantin.
Take the completed application to your physician/prescriber. Residents of the United States, including US Territories, are also eligible. Ifyou believe that you meet the eligibility criteria for the Merck Patient AssistanceProgram and you have received a prescription for a Merck product, calltoll-free 800-727-5400 8 AM to 8 PM Vytorin 313 to obtain a brochure outlining theprogram and an enrollment application, or proceed to Step 4 to download an enrollment form.
Vytorin 313 you do not meet the prescription drug coverage criteria, your income meets the program criteria, and there are special circumstances of financial and medical hardship that apply to your situation, you can vytorin 313 that an exception be made for you. vytorin 313 vytorin 313
Vytorin 313 Due to the increased risk of myopathy, including rhabdomyolysis, associated with the 10/80-mg dose of VYTORIN, patients unable to achieve their LDL-C goal utilizing the 10/40-mg dose of VYTORIN should not vytorin 313 titrated to the 10/80-mg dose, but should be placed on alternative LDL-C-lowering treatmen s that provides greater LDL-C lowering.
Patients who are currently tolerating the 10/80-mg dose of VYTORIN who need to be initiated on an interacting drug that is contraindicated or is associated with a dose vytorin 313 for simvastatin should be switched to an alternative statin or statin-based regimen with less potential for the drug-drug interaction.
Due to the increased risk of myopathy, including rhabdomyolysis, particularly during the first year of treatment, use of the 10/80-mg dose of VYTORIN should be restricted to patients who have been taking VYTORIN 10/80 mg chronically e. 3 m2 After initiation or titration of VYTORIN, lipid levels may be analyzed after 2 or more weeks and dosage adjusted, if needed.
for 12 months or more without evidence of muscle toxicity see Warnings and Precautions 5. vytorin 313