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Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
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ATC codeG04BE03 ( WHO )
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Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
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Responsibility for the text — BENTYL is contraindicated in patients with severe ulcerative colitissee CONTRAINDICATIONS. BENTYL should be used with caution in patients with known or suspected prostatic enlargement, in whom prostatic enlargement may lead to urinary retentionsee ADVERSE REACTIONS BENTYL should be used with caution in patients with known hepatic and renal impairment.

Large doses may suppress intestinal motility to the point of producing a paralytic ileus and the use of this drug may precipitate or aggravate the serious complication of toxic megacolonsee ADVERSE REACTIONS.

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