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MT promoted the hepatic differentiation of MSCs and significantly increased bone morphogenetic protein 2 expression and SMAD1/5/8 phosphorylation by activating the p38, extracellular signal regulated kinase ERK and NF B signalling pathways. 0 Preconditioning with MT significantly improved the homing ability of MSCs in vivo, up regulated the expression of MMPs and Bcl2, and decreased the expression of TGF 1 and Bax, consequently restoring glycogen storage and decreasing collagen and lipid deposition in the fibrotic liver.

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