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TENDRA avanafil Tablets STENDRA avanafil is a selective inhibitor of cGMP-specific PDE5. vanafil is designated chemically as S 4- 3-Chloro-4-methoxybenzyl mino -2- 2 hydroxymethyl 1-pyrrolidinyl - 2-pyrimidinylmethyl 5-pyrimidinecarboxamide and has the following structural formula: vanafil occurs as white crystalline powder, stendra vs viagra formula C23H26ClN7O3 and molecular weight of 483.
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Avana tablets 50mg contain avanafil, a phosphodiesterase type 5 PDE5 inhibitor used to treat erectile dysfunction in men impotence When stendra vs viagra before planned sexual activity, avanafil in Avana tablets 50mg inhibits the breakdown by the enzyme PDE5 of a chemical called cGMP, produced in the erectile tissue of the penis during sexual arousal, and this action allows blood flow into the penis causing an erection.
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Ketoconazole 400 mg daily a selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose Cmax and exposure AUC equal to 3-fold and 14-fold respectively and prolonged the half-life of avanafil to approximately 9 hours.
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During the early interval, the avanafil 100 mg and 200 mg treatments were superior to sildenafil 50 mg for duration of 60 rigidity; however, sildenafil 50 mg was superior to avanafil during the late interval. inutes intervals.
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The doctor will take into account potential drug interactions, your age, the severity of your erectile dysfunction and any previous experience you have had with these medications. The doctor needs to decide which dosage of Spedra is most appropriate.
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An erection that will not go away priapism If you have an erection that lasts more than 4 hours, get medical help right away. You and your healthcare provider should decide Do not drink too much alcohol when taking Stendra vs viagra for stendra vs viagra, 3 glasses of wine, or 3 shots of whiskey Drinking too stendra vs viagra alcohol when taking STENDRA can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.
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Thus, co-administration of lopinavir/ritonavir with drugs highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events is contraindicated. Co-administration with other CYP3A substrates may require a dose adjustment or additional monitoring as shown in Table 5.
Agents that are extensively metabolized by CYP3A and have high first pass metabolism appear to be the most susceptible to large increases in AUC 3-fold when co-administered with lopinavir and ritonavir.
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If you take Spedra when you are stendra vs viagra taking nitrates, the combined effect of the Stendra vs viagra and the nitrates can lower your blood pressure to such an extent that it could prove fatal.
This is not a problem for most men. But Spedra's effect on blood pressure is exaggerated if it is taken with a nitrate drug. Nitrates are one of the treatments doctors prescribe for angina.
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