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Ww. Cymbalta canada pharmacy cymbalta canada pharmacy Generally these symptoms are self-limiting and usually resolve within 2 weeks, though in some cymbalta canada pharmacy they may be prolonged (2-3 months or more) It is therefore advised that duloxetine should be gradually tapered when discontinuing treatment over a period of no less than 2 weeks, according to the patient's needs (see section 4. They usually occur within the first few days of discontinuing treatment, but there have been very rare reports of such symptoms in patients who have inadvertently missed a dose.
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Duloxetine, a recently-developed SNRI, thus appeared to represent an ideal candidate for the treatment of FM. Duloxetine had previously been approved by the FDA for the treatment of major depressive disorder, pain diabetic neuropathy and, more recently, generalized anxiety disorder. However, studies have shown that, in addition to their role in mood and affect, serotonin and norepinephrine play an important role in pain modulation.

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Indeed, studies have indicated that agents capable of dual reuptake are more efficacious than those that inhibit the reuptake of either serotonin or norepinephrine separately. It has also been demonstrated to be an effective analgesic against headache, back pain, stomach aches and regional musculoskeletal pain associated with major depressive disorder, 0 and is effective in reducing pain related to diabetic neuropathy in non-depressed patients.

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