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Because salmeterol is metabolized predominantly in the liver coupon for advair inhaler free potentially may accumulate in the plasma of patients with hepatic impairment, such patients should be monitored closely while receiving salmeterol therapy. Because of the risk of asthma-related death and hospitalization, use of salmeterol for the treatment of asthma without concomitant use of long-term asthma controller therapy, such as inhaled corticosteroids, is contraindicated.

Lower respiratory tract infections, including pneumonia, have been reported in patients with COPD following the administration of inhaled corticosteroids, including fluticasone propionate and the inhalation powder preparation containing salmeterol in fixed combination with fluticasone propionate. Patients should inform their clinician of liver dysfunction prior to initiation of therapy.

The pharmacokinetics of coupon for advair inhaler free have not been studied in patients with hepatic impairment. Clinicians should remain vigilant for the possible development of pneumonia in patients with COPD who are receiving the inhalation powder preparation containing salmeterol in fixed combination with fluticasone propionate Advair Diskus since the clinical features of pneumonia and COPD exacerbations frequently overlap.

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Salmeterol (Serevent Diskus); combination fluticasone/salmeterol ( Advair Diskus or HFA). Diskus: 50 mcg per blister; one puff twice per day.

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In large clinical trials, patients are typically divided into groups with similar risk factors such as age, the severity of their disease and the other drugs they are taking--all of which can affect mortality.

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