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    In a clinical study, the pharmacokinetics of S-warfarin, a CYP2C9 substrate, were not significantly affected by duloxetine see Drug Interactions (7. Results of in vitro studies demonstrate that duloxetine does not inhibit or induce CYP3A activity. 2) Results of in vitro studies demonstrate that duloxetine does not inhibit activity. ...

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    Figure 1: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity - DPNP-1 Figure 1: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity - DPNP-1 Figure 2: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity - DPNP-2 Figure 2: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity - DPNP-2 The efficacy of Duloxetine Delayed-release Capsules in chronic low back pain (CLBP) was assessed in two double-blind, placebo-controlled, randomized clinical trials of 13-weeks duration (Study CLBP-1 and Study CLBP-2) and one of 12-weeks duration (CLBP-3) CLBP-1 and CLBP-3 demonstrated efficacy of Duloxetine Delayed-release Capsules in the treatment of chronic low back pain. Patients in all studies had no signs of radiculopathy or spinal stenosis. Some patients experienced a decrease in pain as early as week 1, which persisted throughout the study. ...

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