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If we did indeed observe changes in methionine synthase mRNA status, it would strongly suggest that alternative splicing of methionine synthase mRNA in blood cells might be a useful marker of oxidative stress status. Based upon our preliminary findings we hypothesize that the Cap domain will be partially spliced under normal growth conditions, but more extensively spliced under conditions of oxidative stress.
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Terms that are reported represent those that occurred at an incidence of 5% and more commonly in patients treated with ACTOS than in patients who received placebo. PROactive Trial: Incidence and Types of Adverse Events Reported in 5% of Patients Treated with ACTOS and More Commonly than Placebo A summary of the incidence of actos 15 mg tab events related to congestive heart failure is provided in Table 6 for the 16-to 24-week add-on to sulfonylurea trials, for the 16-to 24-week add-on to insulin trials, and for the 16-to 24-week add-on to metformin trials and mindsetdigital.com.
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