| American League Leaders | National League Leaders | |||||||
| Batting Average | Batting Average | |||||||
| 1 | Magglio Ordonez | DET | .363 | 1 | Matt Holliday | COL | .340 | |
| 2 | Ichiro Suzuki | SEA | .351 | 2 | Chipper Jones | ATL | .337 | |
| 3 | Placido Polanco | DET | .341 | 3 | Chase Utley | PHI | .332 | |
| 4 | Jorge Posada | NYY | .338 | 4 | Edgar Renteria | ATL | .332 | |
| 5 | David Ortiz | BOS | .332 | 5 | Hanley Ramirez | FLA | .332 | |
| 6 | Chone Figgins | LAA | .330 | 6 | Albert Pujols | STL | .327 | |
| 7 | Mike Lowell | BOS | .324 | 7 | David Wright | NYM | .325 | |
| 8 | Vladimir Guerrero | LAA | .324 | 8 | Miguel Cabrera | FLA | .320 | |
| 9 | Derek Jeter | NYY | .322 | 9 | Dmitri Young | WAS | .320 | |
| 10 | Dustin Pedroia | BOS | .317 | 10 | Todd Helton | COL | .320 | |
| Home Runs | Home Runs | |||||||
| 1 | Alex Rodriguez | NYY | 54 | 1 | Prince Fielder | MIL | 50 | |
| 2 | Carlos Pena | TAM | 46 | 2 | Ryan Howard | PHI | 47 | |
| 3 | Jim Thome | CHW | 35 | 3 | Adam Dunn | CIN | 40 | |
| David Ortiz | BOS | 35 | 4 | Matt Holliday | COL | 36 | ||
| 5 | Paul Konerko | CHW | 31 | 5 | Miguel Cabrera | FLA | 34 | |
| Justin Morneau | MIN | 31 | Ryan Braun | MIL | 34 | |||
| 7 | Jermaine Dye | CHW | 28 | Lance Berkman | HOU | 34 | ||
| Torii Hunter | MIN | 28 | 8 | Carlos Beltran | NYM | 33 | ||
| Magglio Ordonez | DET | 28 | Alfonso Soriano | CHC | 33 | |||
| 10 | Vladimir Guerrero | LAA | 27 | 10 | Albert Pujols | STL | 32 | |
| Carlos Lee | HOU | 32 | ||||||
| Chris Young | ARI | 32 | ||||||
| Runs Batted In | Runs Batted In | |||||||
| 1 | Alex Rodriguez | NYY | 156 | 1 | Matt Holliday | COL | 137 | |
| 2 | Magglio Ordonez | DET | 139 | 2 | Ryan Howard | PHI | 136 | |
| 3 | Vladimir Guerrero | LAA | 125 | 3 | Prince Fielder | MIL | 119 | |
| 4 | Carlos Pena | TAM | 121 | Miguel Cabrera | FLA | 119 | ||
| 5 | Mike Lowell | BOS | 120 | Carlos Lee | HOU | 119 | ||
| 6 | David Ortiz | BOS | 117 | 6 | Brad Hawpe | COL | 116 | |
| 7 | Victor Martinez | CLE | 114 | 7 | Carlos Beltran | NYM | 112 | |
| 8 | Nick Markakis | BAL | 112 | 8 | Garrett Atkins | COL | 111 | |
| 9 | Justin Morneau | MIN | 111 | 9 | David Wright | NYM | 107 | |
| 10 | Torii Hunter | MIN | 107 | 10 | Adam Dunn | CIN | 106 | |
| Wins | Wins | |||||||
| 1 | Josh Beckett | BOS | 20 | 1 | Jake Peavy | SDG | 19 | |
| 2 | C.C. Sabathia | CLE | 19 | 2 | Carlos Zambrano | CHC | 18 | |
| John Lackey | LAA | 19 | Brandon Webb | ARI | 18 | |||
| Chien-Ming Wang | NYY | 19 | 4 | Jeff Francis | COL | 17 | ||
| Fausto Carmona | CLE | 19 | 5 | Tim Hudson | ATL | 16 | ||
| 6 | Kelvim Escobar | LAA | 18 | Brad Penny | LAD | 16 | ||
| Justin Verlander | DET | 18 | Aaron Harang | CIN | 16 | |||
| 8 | Tim Wakefield | BOS | 17 | 8 | Ted Lilly | CHC | 15 | |
| 9 | Miguel Batista | SEA | 16 | Oliver Perez | NYM | 15 | ||
| Roy Halladay | TOR | 16 | John Maine | NYM | 15 | |||
| Cole Hamels | PHI | 15 | ||||||
| Earned Run Average | Earned Run Average | |||||||
| 1 | John Lackey | LAA | 3.01 | 1 | Jake Peavy | SDG | 2.54 | |
| 2 | Fausto Carmona | CLE | 3.06 | 2 | Brandon Webb | ARI | 3.01 | |
| 3 | Dan Haren | OAK | 3.07 | 3 | Brad Penny | LAD | 3.03 | |
| 4 | Erik Bedard | BAL | 3.16 | 4 | John Smoltz | ATL | 3.11 | |
| 5 | C.C. Sabathia | CLE | 3.21 | 5 | Chris Young | SDG | 3.12 | |
| 6 | Josh Beckett | BOS | 3.27 | 6 | Roy Oswalt | HOU | 3.18 | |
| 7 | Johan Santana | MIN | 3.33 | 7 | Tim Hudson | ATL | 3.33 | |
| 8 | Kelvim Escobar | LAA | 3.40 | 8 | Cole Hamels | PHI | 3.39 | |
| 9 | Scott Kazmir | TAM | 3.48 | 9 | Oliver Perez | NYM | 3.56 | |
| 10 | Mark Buehrle | CHW | 3.63 | 10 | Matt Cain | SFO | 3.65 | |
| Strikeouts | Strikeouts | |||||||
| 1 | Scott Kazmir | TAM | 239 | 1 | Jake Peavy | SDG | 234 | |
| 2 | Johan Santana | MIN | 235 | 2 | Aaron Harang | CIN | 218 | |
| 3 | Erik Bedard | BAL | 221 | 3 | John Smoltz | ATL | 197 | |
| 4 | Javier Vazquez | CHW | 213 | 4 | Brandon Webb | ARI | 194 | |
| 5 | C.C. Sabathia | CLE | 209 | 5 | Rich Hill | CHC | 183 | |
| 6 | Daisuke Matsuzaka | BOS | 201 | 6 | John Maine | NYM | 180 | |
| 7 | Josh Beckett | BOS | 194 | 7 | Carlos Zambrano | CHC | 177 | |
| 8 | Dan Haren | OAK | 192 | Ian Snell | PIT | 177 | ||
| 9 | James Shields | TAM | 184 | Cole Hamels | PHI | 177 | ||
| 10 | Justin Verlander | DET | 183 | 10 | Ted Lilly | CHC | 174 | |