Home games are in BOLD. All times are Eastern.
| Date | Time | Result | Record |
| MARCH | |||
| 25 vs Oak* | 6:07 AM | W, 6-5, WP: Okajima LP: Street SV: Papelbon | 1-0 |
| 26 vs Oak* | 6:07 AM | L, 1-5, WP:Harden LP: Lester | 1-1 |
| *Tokyo Dome | |||
| APRIL | |||
| 1 @ oak | 10:07 PM | W, 2-1, WP: Matsuzaka LP: Blanton SV: Papelbon | 2-1 |
| 2 @ oak | 3:37 PM | W, 5-0, WP: Lester LP: Embree | 3-1 |
| 4 @ tor | 7:15 PM | L, 3-6, WP: Marcum LP: Aardsma SV: Accardo | 3-2 |
| 5 @ tor | 1:07 PM | L, 2-10, WP: Litsch LP: Buchholz | 3-3 |
| 6 @ tor | 1:07 PM | L, 4-7, WP: Halladay LP: Beckett SV: Accardo | 3-4 |
| 8 vs DET | 2:05 PM | W, 5-0, WP: Matsuzaka LP: Rogers | 4-4 |
| 9 vs DET | 7:05 PM | L, 2-7, WP: Bonderman LP: Lester | 4-5 |
| 10 vs DET | 7:05 PM | W, 12-6, WP: Wakefield LP: Robertson SV: Papelbon | 5-5 |
| 11 vs NYY | 7:05 PM | L, 1-4, WP: Wang LP: Timlin | 5-6 |
| 12 vs NYY | 3:55 PM | W, 4-3, WP: Beckett LP: Mussina SV: Papelbon | 6-6 |
| 13 vs NYY | 1:35 PM | W, 8-5, WP: Matsuzaka LP: Hughes SV: Delcarmen |
7-6 |
| 14 @ cle | 7:05 PM | W, 6-4, WP: Timlin LP: Borowski SV: Papelbon | 8-6 |
| 15 @ cle | 7:05 PM | W, 5-3, WP: Aardsma LP: Lewis SV: Okajima | 9-6 |
| 16 @ nyy | 7:05 PM | L, 9-15, WP: Hawkins LP: Tavarez SV: Bruney | 9-7 |
| 17 @ nyy | 7:05 PM | W, 7-5, WP: Beckett LP: Mussina | 10-7 |
| 18 vs TEX | 7:05 PM | W, 11-3, WP: Matsuzaka LP: Mendoza | 11-7 |
| 19 vs TEX | 7:05 PM | W, 5-3, WP: Lopez LP: Benoit SV: Papelbon | 12-7 |
| 20 vs TEX | 1:35 PM | W, 6-5, WP: Wakefield LP: Wilson SV: Papelbon | 13-7 |
| 21 vs TEX | 11:05 AM | W, 8-3, WP: Buchholz LP: Nippert | 14-7 |
| 22 vs LAA | 7:05 PM | W, 7-6, WP: Timlin LP: Oliver SV: Papelbon |
15-7 |
| 23 vs LAA | 7:05 PM | L, 4-6, WP: Garland LP: Hansen SV: K-Rod |
15-8 |
| 24 vs LAA | 1:35 PM | L, 5-7, WP: Saunders LP: Delcarmen SV: K-Rod | 15-9 |
| 25 @ tb | 7:10 PM | L, 4-5, WP: Dohmann LP: Timlin | 15-10 |
| 26 @ tb | 7:10 PM | L, 1-2, WP: Dohmann LP: Buchholz SV: Percival | 15-11 |
| 27 @ tb | 1:40 PM | L, 0-3, WP: Shields LP: Beckett | 15-12 |
| 29 vs TOR | 7:05 PM | W, 1-0, WP: Papelbon LP: Halladay |
16-12 |
| 30 vs TOR | 7:05 PM | W, 2-1, WP: Papelbon LP: Downs | 17-12 |
| MAY | |||
| 1 vs TOR | 7:05 PM | L, 0-3, WP: Burnett LP: Wakefield SV: Ryan | 17-13 |
| 2 vs TB | 7:05 PM | W, 7-3, WP: Buchholz LP: Jackson |
18-13 |
| 3 vs TB | 7:05 PM | W, 12-4, WP: Beckett LP: Shields | 19-13 |
| 4 vs TB | 1:35 PM | W, 7-3, WP: Lester LP: Kazmir SV: Papelbon | 20-13 |
| 5 @ det | 7:05 PM | W, 6-3, WP: Matsuzaka LP: Bonderman SV: Papelbon | 21-13 |
| 6 @ det | 7:05 PM | W, 5-0, WP: Wakefield LP: Robertson |
22-13 |
| 7 @ det | 7:05 PM | L, 9-10, WP: Jones LP: Papelbon | 22-14 |
| 8 @ det | 7:05 PM | W, 5-1, WP: Beckett LP: Verlander |
23-14 |
| 9 @ min | 8:10 PM | L, 6-7, WP: Crain LP: Papelbon | 23-15 |
| 10 @ min | 7:10 PM | W, 5-2, WP: Matsuzaka LP: Perkins SV: Papelbon |
24-15 |
| 11 @ min | 2:10 PM | L, 8-9, WP: Blackburn LP: Wakefield SV: Nathan |
24-16 |
| 12 @ min | 8:10 PM | L, 3-7, WP: Hernandez LP: Buchholz | 24-17 |
| 13 @ bal | 7:05 PM | L. 4-5, WP: Guthrie LP: Beckett SV: Sherrill | 24-18 |
| 14 @ bal | 3:05 PM | L, 3-6, WP: Cabrera LP: Hansen SV: Sherrill |
24-19 |
| 17 vs MIL | 3:55 PM | W, 5-2, WP: Matsuzaka LP: Suppan SV: Papelbon |
25-19 |
| 17 vs MIL | 8:35 PM | W, 7-6, WP: Hansen LP: Torres SV: Timlin |
26-19 |
| 18 vs MIL | 1:35 PM | W, 11-7, WP: Beckett LP: Villanueva |
27-19 |
| 19 vs KC | 7:05 PM | W, 7-0, WP: Lester LP: Hochevar | 28-19 |
| 20 vs KC | 7:05 PM | W, 2-1, WP: Masterson LP: Meche SV: Papelbon |
29-19 |
| 21 vs KC | 7:05 PM | W, 6-3, WP: Colon LP: Tomko |
30-19 |
| 22 vs KC | 1:35 PM | W, 11-8, WP: Matsuzaka LP: Bannister SV: Papelbon |
31-19 |
| 23 @ oak | 10:07 PM | L, 3-8, WP: Harden LP: Wakefield |
31-20 |
| 24 @ oak | 9:07 PM | L, 0-3, WP: Duchscherer LP: Beckett SV: Street |
31-21 |
| 25 @ oak | 4:07 PM | L, 3-6, WP: Blanton LP: Lester SV: Street |
31-22 |
| 26 @ sea | 10:10 PM | W, 5-3, WP: Colon LP: Hernandez |
32-22 |
| 27 @ sea | 10:10 PM | L, 3-4, WP: Putz LP: Timlin |
32-23 |
| 28 @ sea | 10:10 PM | L, 0-1, WP: Bedard LP: Wakefield SV: Putz |
32-24 |
| 30 @ bal | 7:05 PM | W, 5-2, WP: Timlin LP: Bradford SV: Papelbon |
33-24 |
| 31 @ bal | 7:05 PM | W, 6-3, WP: Aardsma LP: Cormier SV: Papelbon |
34-24 |
| JUNE | |||
| 1 @ bal | 1:35 PM | W, 9-4 WP: Colon LP: Burres |
35-24 |
| 2 @ bal | 7:05 PM | L, 3-6, WP: Johnson LP: Okajima SV: Sherrill |
35-25 |
| 3 vs TB | 7:05 PM | W, 7-4, WP: Masterson LP: Garza SV: Papelbon |
36-25 |
| 4 vs TB | 7:05 PM | W, 5-1, WP: Beckett LP: Jackson |
37-25 |
| 5 vs TB | 6:05 PM | W, 7-1, WP: Lester LP: Shields |
38-25 |
| 6 vs SEA | 7:05 PM | L, 0-8, WP: Hernandez LP: Colon |
38-26 |
| 7 vs SEA | 3:55 PM | W, 11-3, WP: Wakefield LP: Batista |
39-26 |
| 8 vs SEA | 1:35 PM | W, 2-1 WP: Masterson LP: Green SV: Papelbon |
40-26 |
| 10 vs BAL | 6:05 PM | L, 6-10, WP: Sarfate LP: Okajima |
40-27 |
| 11 vs BAL | 7:05 PM | W, 6-3, WP: Colon LP: Olson SV: Papelbon |
41-27 |
| 12 vs BAL | 6:05 PM | W, 9-2, WP: Lester LP: Guthrie |
42-27 |
| 13 @ cin | 7:10 PM | L, 1-3, WP: Harang LP: Masterson SV: Cordero |
42-28 |
| 14 @ cin | 3:55 PM | W, 6-4, WP: Papelbon LP: Lincoln SV: Hansen |
43-28 |
| 15 @ cin | 1:15 PM | W, 9-0, WP: Beckett LP: Bailey |
44-28 |
| 16 @ phi | 7:05 PM | L, 2-8, WP: Hamels LP: Colon |
44-29 |
| 17 @ phi | 7:05 PM | W, 3-0, WP: Lester LP: Moyer SV: Papelbon |
45-29 |
| 18 @ phi | 1:05 PM | W, 7-4 WP: Masterson LP: Kendrick SV: Papelbon |
46-29 |
| 20 vs STL | 7:05 PM | L, 4-5, WP: Lohse LP: Wakefield SV: Franklin |
46-30 |
| 21 vs STL | 3:55 PM | L, 3-9, WP: Boggs LP: Matsuzaka |
46-31 |
| 22 vs STL | 1:35 PM | W, 5-3, WP: Lopez LP: Parisi |
47-31 |
| 23 vs AZ | 7:05 PM | L, 1-2, WP: Haren LP: Beckett SV: Lyon | 47-32 |
| 24 vs AZ | 7:05 PM | W, 5-4, WP: Smith LP: Qualls SV: Papelbon |
48-32 |
| 25 vs AZ | 7:05 PM | W, 5-0, WP: Wakefield LP: Johnson SV: Papelbon |
49-32 |
| 27 @ hou | 8:05 PM | W, 6-1, WP: Matsuzaka LP: Hernandez SV: Papelbon |
50-32 |
| 28 @ hou | 7:05 PM | L; 10-11, WP: Brocail LP: Delcarmen SV: Valverde |
50-33 |
| 29 @ hou | 2:05 PM | L, 2-3, WP: Brocail LP: Aardsma SV: Valverde |
50-34 |
| 30 @ tb | 7:10 PM | L, 4-5, WP: Shields LP: Masterson SV: Howell |
50-35 |
| JULY | |||
| 1 @ tb | 7:10 PM | L, 1-3, WP: Garza LP: Wakefield SV: Balfour |
50-36 |
| 2 @ tb | 7:10 PM | L, 6-7, WP: Glover LP: Hansen SV: Wheeler |
50-37 |
| 3 @ nyy | 7:05 PM | W, 7-0, WP: Lester LP: Pettitte |
51-37 |
| 4 @ nyy | 1:05 PM | W, 6-4, WP: Beckett LP: Rasner SV: Papelbon |
52-37 |
| 5 @ nyy | 3:55 PM | L, 1-2, WP: Mussina LP: Masterson SV: Rivera |
52-38 |
| 6 @ nyy | 8:05 PM | L, 4-5, WP: Rivera LP: Papelbon |
52-39 |
| 7 vs MIN | 7:05 PM | W, 1-0, WP: Okajima LP: Bass SV: Papelbon |
53-39 |
| 8 vs MIN | 7:05 PM | W, 6-5, WP: Aardsma LP: Guerrier SV: Papelbon |
54-39 |
| 9 vs MIN | 1:05 PM | W, 18-5, WP: Beckett LP: Hernandez |
55-39 |
| 11 vs BAL | 7:05 PM | L, 3-7, WP: Burres LP: Buchholz SV: Sherrill |
55-40 |
| 12 vs BAL | 7:05 PM | W, 12-1 WP: Wakefield LP: Liz |
56-40 |
| 13 vs BAL | 1:35 PM | W, 2-1, WP: Matsuzaka LP: Cabrera SV: Papelbon |
57-40 |
| 18 @ laa | 10:05 PM | L, 3-11, WP: Lackey LP: Buchholz |
57-41 |
| 19 @ laa | 3:55 PM | L, 2-4, WP: Arredondo LP: Beckett SV: KRod |
57-42 |
| 20 @ laa | 6:05 PM | L, 3-5, WP: Oliver LP: Wakefield SV: KRod |
57-43 |
| 21 @ sea | 10:10 PM | W, 4-0, WP: Lester LP: Washburn SV: Papelbon |
58-43 |
| 22 @ sea | 10:10 PM | W, 4-2, WP: Matsuzaka LP: Dickey SV: Papelbon |
59-43 |
| 23 @ sea | 4:40 PM | W, 6-3, WP: Papelbon LP: Green SV: Hansen |
60-43 |
| 25 vs NYY | 7:05 PM | L, 0-1, WP: Chamberlain LP: Beckett SV: Rivera |
60-44 |
| 26 vs NYY | 3:55 PM | L, 3-10, WP: Pettitte LP: Wakefield |
60-45 |
| 27 vs NYY | 8:05 PM | W, 9-2, WP: Lester LP: Ponson |
61-45 |
| 28 vs LAA | 7:05 PM | L, 3-5, WP: Weaver LP: Matsuzaka SV: KRod |
61-46 |
| 29 vs LAA | 7:05 PM | L, 2-6, WP: Lackey LP: Buchholz |
61-47 |
| 30 vs LAA | 7:05 PM | L, 2-9 WP: Saunders LP: Beckett |
61-48 |
| AUGUST | |||
| 1 vs OAK | 7:05 PM | W, 2-1, WP: Timlin LP: Embree |
62-48 |
| 2 vs OAK | 7:05 PM | W, 12-2, WP: Lester LP: Eveland |
63-48 |
| 3 vs OAK | 1:35 PM | W, 5-2, WP: Matsuzaka LP: Braden SV: Papelbon |
64-48 |
| 4 @ kc | 8:10 PM | L, 3-4, WP: Meche LP: Buchholz SV: Soria |
64-49 |
| 5 @ kc | 8:10 PM | W, 8-2, WP: Beckett LP: Bannister |
65-49 |
| 6 @ kc | 8:10 PM | W, 8-2, WP: Wakefield LP: Hochevar |
66-49 |
| 8 @ cws | 8:11 PM | L, 3-5, WP: Buehrle LP: Lester SV: Jenks |
66-50 |
| 9 @ cws | 7:05 PM | W, 6-2, WP: Matsuzaka LP: Logan |
67-50 |
| 10 @ cws | 2:05 PM | L, 5-6, WP: Floyd LP: Buchholz SV: Jenks |
67-51 |
| 11 @ cws | 8:11 PM | W, 5-1, WP: Beckett LP: Danks |
68-51 |
| 12 vs TEX | 7:05 PM | W, 19-17, WP: Okajima LP: Francisco SV: Papelbon | 69-51 |
| 13 vs TEX | 7:05 PM | W, 8-4, WP: Lester LP: Mendoza | 70-51 |
| 14 vs TEX | 7:05 PM | W, 10-0 WP: Matsuzaka LP: Hunter |
71-51 |
| 15 vs TOR | 7:05 PM | Rained out |
PPD |
| 16 vs TOR | 7:05 PM | L, 1-4, WP: Halladay LP: Byrd | 71-52 |
| 17 vs TOR | 1:35 PM | L, 4-15, WP: Marcum LP: Beckett |
71-53 |
| 18 @ bal | 7:05 PM | W, 6-3 WP: Lester LP: Guthrie SV: Papelbon |
72-53 |
| 19 @ bal | 7:05 PM | W, 7-2 WP: Matsuzaka LP: Cabrera |
73-53 |
| 20 @ bal | 7:05 PM | L, 6-11 WP: Waters LP: Buchholz |
73-54 |
| 22 @ tor | 7:07 PM | W, 8-4, WP: Byrd LP: Marcum |
74-54 |
| 23 @ tor | 1:07 PM | L, 0-11, WP: Litsch LP: Lester |
74-55 |
| 24 @ tor | 1:07 PM | W, 6-5, WP: Papelbon LP: League SV: Delcarmen |
75-55 |
| 26 @ nyy | 7:05 PM | W, 7-3, WP: Wakefield LP: Pettitte SV: Papelbon |
76-55 |
| 27 @ nyy | 7:05 PM | W, 11-3, WP: Byrd LP: Ponson |
77-55 |
| 28 @ nyy | 1:05 PM | L, 2-3, WP: Rivera LP: Masterson |
77-56 |
| 29 vs CWS | 7:05 PM | W, 8-0, WP: Matsuzaka LP: Vazquez |
78-56 |
| 30 vs CWS | 7:05 PM | W, 8-2, WP: Bowden LP: Buehrle |
79-56 |
| 31 vs CWS | 1:35 PM | L, 2-4, WP: Floyd LP: Wakefield SV: Jenks |
79-57 |
| SEPTEMBER | |||
| 1 vs BAL | 7:05 PM | W, 7-4, WP: Byrd LP: Olson SV: Papelbon |
80-57 |
| 2 vs BAL | 7:05 PM | W, 14-2, WP: Lester LP: Liz |
81-57 |
| 3 vs BAL | 1:35 PM | W, 5-4, WP: Masterson LP: Miller |
82-57 |
| 5 @ tex | 8:05 PM | W, 8-1, WP: Beckett LP: Millwood |
83-57 |
| 6 @ tex | 8:05 PM | L, 8-15, WP: Harrison LP: Wakefield |
83-58 |
| 7 @ tex | 3:05 PM | W, 7-2, WP: Byrd LP: McCarthy |
84-58 |
| 8 vs TB | 7:05 PM | W, 3-0, WP: Lester LP: Jackson SV: Papelbon |
85-58 |
| 9 vs TB | 7:05 PM | L, 4-5, WP: Dohmann LP: Papelbon SV: Percival |
85-59 |
| 10 vs TB | 7:05 PM | L, 2-4, WP: Miller LP: Timlin SV: Hammel |
85-60 |
| 12 vs TOR | 7:05 PM | W, 7-0, WP: Wakefield LP: Purcey |
86-60 |
| 13 vs TOR | 12:35 PM | L, 1-8, WP: Burnett LP: Byrd |
86-61 |
| 13 vs TOR | 7:05 PM | W, 7-5, WP: Masterson LP: Downs SV: Papelbon |
87-61 |
| 14 vs TOR | 1:35 PM | W, 4-3, WP: Lester LP: Halladay SV: Papelbon |
88-61 |
| 15 @ tb | 7:10 PM | W, 13-5, WP: Matsuzaka LP: Kazmir |
89-61 |
| 16 @ tb | 7:10 PM | L, 1-2, WP: Wheeler LP: Masterson |
89-62 |
| 17 @ tb | 7:10 PM | L, 3-10, WP: Balfour LP: Wakefield |
89-63 |
| 19 @ tor | 7:07 PM | W, 4-3, WP: Delcarmen LP: Tallet SV: Papelbon |
90-63 |
| 20 @ tor | 1:07 PM | L, 3-6, WP: Halladay LP: Lester SV: Ryan |
90-64 |
| 21 @ tor | 1:07 PM | W, 3-0 WP: Matsuzaka LP: Richmond SV: Papelbon |
91-64 |
| 22 vs CLE | 7:05 PM | L, 3-4, WP: Jackson LP: Beckett SV: Lewis |
91-65 |
| 23 vs CLE | 7:05 PM | W, 5-4, WP: Wakefield LP: Lee SV: Papelbon |
92-65 |
| 24 vs CLE | 7:05 PM | W, 5-4, WP: Aardsma LP: Perez SV: Delcarmen |
93-65 |
| 25 vs CLE | 7:05 PM | W, 6-1, WP: Lester LP: Sowers |
94-65 |
| 26 vs NYY | 7:05 PM | L, 8-19, WP: Robertson LP: Pauley |
94-66 |
| 28 vs NYY | 1:35 PM | L, 2-6, WP: Mussina LP: Matsuzaka SV: Rivera |
94-67 |
| 28 vs NYY | 1:35 PM | W, 4-3, WP: Hansack LP: Veras |
95-67 |
Spring Training Schedule
Home games are in BOLD. All times are Eastern.
| DATE | OPPONENT | SITE | TIME |
| 2/28 | Boston College (SS) | City of Palms Park | W, 24-0 |
| Northeastern (SS) | City of Palms Park | W, 15-0 | |
| 2/29 | Twins | Hammond Stadium | W, 8-3 |
| 3/1 | Twins | Hammond Stadium | W, 7-6 |
| 3/2 | Twins | City of Palms Park | L, 2-8 |
| 3/3 | Marlins | Jupiter | L, 2-3 |
| 3/4 | Pirates | City of Palms Park | W, 5-3 |
| 3/5 | Reds | City of Palms Park | L, 6-7 |
| 3/6 | Dodgers | City of Palms Park | L, 6-9 |
| 3/7 | Twins (SS) | City of Palms Park | L, 2-7 |
| Orioles (SS) | Fort Lauderdale | L, 2-12 | |
| 3/8 | Marlins | City of Palms Park | L, 2-5 |
| 3/9 | Dodgers | Vero Beach | L, 0-4 |
| 3/10 | Mets | Port St. Lucie | T, 1-1 |
| 3/11 | Mets | City of Palms Park | W, 4-3 |
| 3/12 | Twins | Hammond Stadium | W, 12-7 |
| 3/13 | Rays | City of Palms Park | T, 3-3 |
| 3/14 | Orioles | City of Palms Park | W, 7-4 |
| 3/15 | Reds | City of Palms Park | W, 16-6 |
| 3/16 | Pirates | Bradenton | L, 3-6 |
| 3/17 | Yankees | Tampa | L, 4-8 |
| 3/19 | Blue Jays | City of Palms Park | L, 3-4 |
| 3/22 | Hanshin Tigers | Tokyo Dome | W, 6-5 |
| 3/23 | Yomiuri Giants | Tokyo Dome | W, 9-2 |
| 3/25 | A’s (Reg. Season) | Tokyo Dome | W, 6-5 |
| 3/26 | A’s (Reg. Season) | Tokyo Dome | L, 1-5 |
| 3/28 | Dodgers | Dodger Stadium | L, 1-3 |
| 3/29 | Dodgers | Memorial Coliseum | W, 7-4 |
| 3/30 | Dodgers | Dodger Stadium | L, 0-8 |
| (SS) — Split Squad | |||
| NPB-Nippon Professional Baseball | |||
